Dry Age-Related Macular Degeneration Market Insights 2024

What Is the Current Market Size and Growth Rate for Each Stage of Dry AMD?

The Dry Age-Related Macular Degeneration (AMD) market is projected to grow significantly in the coming years.

The global dry AMD market size is expected to reach USD 17.92 billion by 2032, with a compound annual growth rate (CAGR) of 8.2%. This growth is largely driven by the increasing aging population and the rising incidence of dry AMD, particularly in developed countries with longer life expectancies.

Breaking down the market by stages:

• Early Dry AMD: This segment has no approved treatments yet, but with ongoing clinical trials, it holds future growth potential.
• Intermediate Dry AMD: This stage holds the largest market share, contributing over 45% to the overall dry AMD market. It is expected to continue its dominance due to ongoing research and diagnosis methods.
• Late Dry AMD (Geographic Atrophy): The market for late-stage dry AMD, also known as geographic atrophy, is set to expand as innovative treatments progress in clinical trials, such as Zimura by Iveric Bio.

What Are the Prevalent Treatment Options for Each Stage of Dry AMD?

Currently, the treatment landscape for dry AMD is limited, particularly in the early and intermediate stages where there are no FDA-approved therapies.

However, lifestyle changes, dietary supplements (AREDS vitamins), and regular monitoring are recommended to manage progression.

For late-stage dry AMD (geographic atrophy), recent advances show promise. One of the leading treatments in the pipeline is Zimura (avacincaptad pegol), an inhibitor of complement C5, which has shown positive results in reducing the progression of geographic atrophy.

Companies like Iveric Bio and Apellis Pharmaceuticals are at the forefront of developing therapies that target complement pathways, a key factor in dry AMD progression.

Latest Technologies and Innovations:

• Zimura (Iveric Bio): Complement C5 inhibitor to slow the progression of geographic atrophy.
• Pegcetacoplan (Apellis Pharmaceuticals): Another complement pathway inhibitor, targeting C3 for managing geographic atrophy.
• Gene Therapy: Companies like Ocumension Therapeutics and Eyestem Research are exploring gene therapies that could potentially address the root causes of AMD by targeting retinal cell regeneration.

Which Companies Are Leading in Research and Development for Dry AMD Treatments?

The dry AMD market is a hotbed for pharmaceutical innovation, with several key players dominating the landscape through extensive R&D pipelines. These companies include:

• Santen Pharmaceuticals Inc. (Japan): Known for its robust ophthalmic research, Santen is actively exploring novel treatment options for dry AMD.
• Allergan plc (Ireland): A leader in eye care, Allergan continues to invest heavily in AMD research, particularly in geographic atrophy treatments.
• Bausch Health (Canada): This Canadian giant is focusing on developing non-invasive therapies to target dry AMD progression.
• Alimera Science Inc. (US): Specialized in developing therapies for retinal diseases, Alimera is focused on delivering innovative solutions for dry AMD.
• Phio Pharmaceuticals Corp (US): Exploring RNAi therapies, Phio Pharmaceuticals is investigating the genetic underpinnings of AMD.
• Ocumension Therapeutics Co. Ltd (China): Leading in gene therapies and novel drug delivery methods for AMD patients.
• Belite Bio Inc. (US) and Kubota Vision Inc. (US): Both companies are working on therapies targeting the metabolic pathways involved in dry AMD.
• Iveric Bio (US): Leading the charge with Zimura, their innovative geographic atrophy treatment.
• Eyestem Research Pvt Ltd (India): Focused on stem cell research to restore vision in AMD patients.

What Are the Key Market Trends and Unmet Needs in the Dry AMD Sector?

The dry AMD market is marked by significant unmet needs, particularly in the early and intermediate stages where treatment options remain scarce.

The market is experiencing growing demand for novel therapies that can halt or slow disease progression before it reaches the late stage (geographic atrophy).

Emerging Market Trends:

• Targeted Therapies: Companies are focusing on complement pathway inhibitors (like Zimura) and RNAi-based therapies to target the disease at a molecular level.
• Stem Cell Therapies: Firms like Eyestem Research are pioneering stem cell-based approaches to regenerate retinal cells damaged by dry AMD.
• Gene Therapies: Innovations from Ocumension Therapeutics and Kubota Vision are exploring gene therapy approaches to correct genetic abnormalities linked to AMD.
• Artificial Intelligence (AI): AI is increasingly being used to detect early signs of dry AMD and monitor disease progression, enabling earlier intervention.

Despite these advancements, there remains a critical need for preventive therapies and effective early-stage treatments, particularly as the global aging population continues to expand. Companies with robust pipelines, like Iveric Bio and Allergan, are positioned to capitalize on these opportunities.

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